---
title: CSD-CrossMiner Scaffold Hopping
description: This white paper details how to identify novel lead compounds using scaffold hopping in CSD-CrossMiner.
---

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# Move Forward Faster - Reduce Frustration from Weak Hits

## **![Crossminerhand](https://info.ccdc.cam.ac.uk/hs-fs/hubfs/Crossminerhand.png?width=182&height=182&name=Crossminerhand.png)White Paper** 

## Identification of Novel Lead Compounds using Scaffold Hopping in CSD-CrossMiner 

 

 

How confident are you that the hits you’re progressing are strong, high-quality and commercially viable?

In many hit-to-lead programmes, teams face a combination of frustrations: early designs that don’t hold up, false positives consuming downstream resources, and limited scaffold diversity leading to IP constraints later on.

CSD-CrossMiner brings structure-driven insight earlier into your workflow, enabling you to make faster and better-informed decisions from the start.

### **Download the White Paper To Learn How To:**

- Search and retrieve novel scaffolds from world-leading databases—like the Cambridge Structural Database (CSD) and the Protein Data Bank (PDB).
- Improve design quality upfront, accelerating hit-to-lead progression with stronger, more reliable candidates.
- Reduce false positives, focusing time and budget on hits with robust interaction profiles.
- Minimise IP risk by systematically identifying diverse, patentable scaffold alternatives early through scaffold hopping.

 

### WHITE PAPER DOWNLOAD

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