A knowledge-based approach to improving effectiveness, quality and risk assessment in the development of solid formulations of drugs, agrochemicals and molecular materials.

In this white paper we introduce a knowledge based approach to improving effectiveness, quality and risk assessment in the development of solid formulations of drugs, agrochemicals and molecular materials

 

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Landing page - whitepaper healthchecks - August 2019

  • The cost of failure: We discuss the potential harm that can occur as a result of unaddressed gaps in the understanding of polymorphism in solid form behaviours, especially in late stage development and post product launch, and we review the well-renowned case studies including ritonavir and rotigotine

  • Managing risk: We look at ways to manage these risks and improve reliability of solid state development
    The Crystal Form Consortium (CFC) - we discuss how this forum aims to address the lack of rational design tools for solid form development

  • The 'healthcheck' methodology:  We explain how a pro-active evaluation of crystal structures of active ingredients is now routine in a number of organisations

  • Benefits of adopting Solid Form Informatics:  We look at how it possible to prevent potential disasters such as that of ritonavir and rotigotine with Solid Form Informatics

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